Detrended fluctuation analysis in the presurgical evaluation of parietal lobe epilepsy patients

To examine the usability of long-range temporal correlations (LRTCs) in non-invasive localization epileptogenic zone (EZ) refractory parietal lobe epilepsy (RPLE) patients. We analyzed 10 RPLE patients who had presurgical MEG and underwent surgery. quantified LRTCs with detrended fluctuation analysis (DFA) at four frequency bands for 200 cortical regions estimated using individual source models. correlated individually DFA maps to distance from resection area locations interictal epileptiform discharges (IEDs). Additionally, three clinical experts inspected visually assess most likely EZ locations. The type II focal dysplasia (FCD) (p<0.05), but not other etiologies. Similarly, IED only FCD Visual showed high interobserver agreement accuracy assigning affected hemisphere lobe. Aberrant correlate areas This methodological pilot study demonstrates feasibility approximating that may aid provide new insight into evaluation epilepsy.